ʻO ka hopena ʻaoʻao ʻo Florfenicol

       Florfenicolhe synthetic monofluoro derivative o thiamphenicol, ʻo ka molecular formula C12H14Cl2FNO4S, keʻokeʻo a keʻokeʻo keʻokeʻo crystalline pauka, ʻaʻala ʻole, hiki ke hoʻoheheʻe ʻia i ka wai a me ka chloroform, hiki ke hoʻoheheʻe ʻia i loko o ka glacial acetic acid, soluble i ka Methanol, ethanol.He lāʻau antibiotic hou ia o ka chloramphenicol no ka hoʻohana holoholona holoholona, ​​​​i hoʻomohala maikaʻi ʻia i ka hopena o nā makahiki 1980.

Ua kūʻai mua ʻia ma Iapana i ka makahiki 1990. I ka makahiki 1993, ua ʻae ʻo Norewai i ka lāʻau lapaʻau e mālama ai i ka furuncle o salmon.I ka makahiki 1995, ua ʻae ʻo Farani, United Kingdom, Austria, Mexico a me Sepania i ka lāʻau lapaʻau no ka mālama ʻana i nā maʻi bacterial respiratory bovine.Ua ʻae ʻia no ka hoʻohana ʻana ma ke ʻano he mea hānai puaʻa ma Iapana a me Mexico e pale a mālama i nā maʻi bacterial i loko o nā puaʻa, a ua ʻae ʻo Kina i ka lāʻau lapaʻau.

He lāʻau antibiotic ia, e hoʻopuka ana i kahi hopena bacteriostatic ākea ākea ma ke kāohi ʻana i ka hana o ka peptidyltransferase, a he ākea antibacterial spectrum, me nā ʻano like ʻole.Gram-maikaʻia me ka maʻi bacteria maikaʻi ʻole a me ka mycoplasma.ʻO nā maʻi bacteria koʻikoʻi e pili ana i ka bovine a me ka porcine Haemophilus,Shigella dysenteriae, Salmonella, Escherichia coli, Pneumococcus, Influenza bacillus, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, Rickettsia, etc. Hiki i kēia huahana ke diffuse i loko o nā cell bacteria ma o lipid solubility, hana nui ma ka 50s subunit o bacterial 70s transpeptidase, in hihibits ribosomes. ka ulu ʻana o ka peptidase, kaohi i ka hoʻokumu ʻana o nā kaulahao peptide, a laila e pale ai i ka synthesis protein, e hoʻokō ai i ke kumu Antibacterial.Hoʻopili koke ʻia kēia huahana e ka hoʻokele waha, hoʻolaha nui ʻia, he lōʻihi ka hapalua o ke ola, kiʻekiʻe ke koʻikoʻi o ka lāʻau lapaʻau, a me ka manawa mālama lāʻau koko lōʻihi.
I nā makahiki i hala iho nei, ua hoʻohana nui nā māla puaʻa liʻiliʻi a liʻiliʻi i ka florfenicol no ka mālama ʻana me ka nānā ʻole i ke kūlana o nā puaʻa, a hoʻohana i ka florfenicol ma ke ʻano he lāʻau kilokilo.ʻOiaʻiʻo, pilikia loa kēia.He hopena therapeutic maikaʻi ia i nā maʻi puaʻa i hoʻokumu ʻia e ka Gram-positive a me nā bacteria maikaʻi ʻole a me mycoplasma, ʻoi aku ma hope o ka hui pū ʻana o florfenicol a me doxycycline, hoʻonui ʻia ka hopena, a he mea maikaʻi ia i ka mālama ʻana i ka puaʻa thoracic swine atrophic rhinitis kaulahao.He hopena maikaʻi ko Cocci, etc.
Eia naʻe, ʻo ke kumu o ka pōʻino o ka hoʻohana mau ʻana i ka florfenicol no ka mea he nui nā hopena ʻaoʻao o ka florfenicol, a ʻoi aku ka maikaʻi o ka hoʻohana lōʻihi ʻana i ka florfenicol.No ka laʻana, ʻaʻole pono e haʻalele nā ​​hoa puaʻa i kēia mau kikoʻī.

1. Inā loaʻa nā maʻi viral e like me ka pseudorabies swine fever me ke apo pepeiao uliuli i loko o ka māla puaʻa, ʻo ka hoʻohana ʻana i ka florfenicol no ka mālama ʻana e lilo pinepine ia i mea hoʻohui i kēia mau maʻi viral, no laila inā ua loaʻa nā maʻi ma luna a loaʻa ma hope. ʻO nā maʻi puaʻa'ē aʻe, mai hoʻohana i ka florfenicol no ka mālamaʻana, e hoʻonui i ka maʻi.
2. E hoʻopilikia ʻo Florfenicol i kā mākou ʻōnaehana hematopoietic a keʻakeʻa i ka hana ʻana o nā keʻena koko ʻulaʻula i loko o ka iwi iwi, ʻoi aku ka nui inā he anu a pehu paha nā hui o kā mākou puaʻa hānai.ʻAʻole maikaʻi ke kala lauoho puaʻa, lauoho palai, akā hōʻike pū kekahi i nā hōʻailona o ka anemia, ʻaʻole ia e ʻai lōʻihi ka puaʻa, hana i ka puaʻa ʻoʻoleʻa.
3. He embryotoxic ka Florfenicol.Inā hoʻohana pinepine ʻia ka florfenicol i ka wā hāpai i nā lūlū, e hāʻule nā ​​​​hua puaʻa.
4. ʻO ka hoʻohana lōʻihi ʻana i ka florfenicol e hōʻeha i ka maʻi ʻōpū a me ka maʻi maʻi puaʻa.
5. He mea maʻalahi ke kumu o ka maʻi lua, e like me ka exudative dermatitis i hoʻokumu ʻia e ka maʻi staphylococcus i loko o nā puaʻa a i ʻole ka maʻi lua o kekahi dermatitis fungal.
I ka hōʻuluʻulu ʻana, ʻaʻole pono e hoʻohana ʻia ka florfenicol ma ke ʻano he lāʻau lapaʻau maʻamau.Ke hoʻohana mākou i nā lāʻau antibiotic ʻē aʻe me ka hopena maikaʻi ʻole a i loko o kahi manaʻo hui ʻia (expel virus), hiki iā mākou ke hoʻohana i ka florfenicol a me ka doxycycline ma ka ʻaoʻao.Hoʻohana ʻia ka Acupuncture no ka mālama ʻana i nā maʻi intractable, ʻaʻole ʻōlelo ʻia no nā kūlana ʻē aʻe.