He maʻi paʻakikī mau ka maʻi hanu puaʻa e hoʻopilikia nei i nā mea nona ka mahiʻai puaʻa. He paʻakikī ke kumu, he ʻokoʻa nā pathogens, ākea ka laha, a he paʻakikī ka pale ʻana a me ka kaohi ʻana, kahi e lawe mai ai i nā pohō nui i nā mahiʻai puaʻa. I nā makahiki i hala iho nei, hōʻike pinepine nā maʻi hanu puaʻa i nā maʻi hui like ʻole, no laila ua maʻa mākou e kapa iā ia he maʻi hanu mahiʻai puaʻa. ʻO nā pathogens maʻamau e komo pū me Mycoplasma, Haemophilus parasuis, Actinobacillus pleuropneumoniae, pepeiao polū, circovirus a me ka maʻi puaʻa.
No ka pale ʻana a me ka mālama ʻana i nā maʻi hanu, he hopena maikaʻi ko tilmicosin
ʻO nā pathogens hanu o nā puaʻa ua māhele nui ʻia i nā bacteria, nā virus a me ka mycoplasma. No ka mycoplasma a me ka porcine infectious pleuropneumonia, ua hoʻomohala nā antibiotics maʻamau o kēia manawa i ke kūʻē, a ua hoʻohana pinepine ʻia kahi hanauna hou o nā antibiotics i ke ʻano lapaʻau e pale a mālama i nā maʻi hanu puaʻa. No ka laʻana, ʻo tilmicosin, doxycycline, tyvalomycin, a me nā mea ʻē aʻe, me ka lāʻau lapaʻau antiviral kuʻuna Kina, he hopena koʻikoʻi. Ua hōʻike ʻia nā haʻawina he hopena antiviral hapa ko tilmicosin, a he hopena maikaʻi kona i ka kaohi ʻana i ka maʻi hanu puaʻa e pili ana me ka porcine PRRS.
ʻO Tilmicosinhe kaʻina hana hohonu a he nui nā pono o ka uhi ʻana i ka papa pālua.
E like me kā kākou e ʻike nei, ʻo tilmicosin kekahi o nā lāʻau lapaʻau kūpono loa no ka kaohi ʻana i nā maʻi hanu ma nā mahi puaʻa. Eia nō naʻe, ʻaʻole like nā hopena o nā tilmicosin like ʻole ma ka mākeke. No ke aha mai kēia? Pehea lā e hiki ai iā kākou ke hoʻokaʻawale ma waena o lākou? Pehea lā ka ʻokoʻa? No ka tilmicosin, ua aneane like nā mea maka, a ʻaʻohe nui o ka ʻokoʻa. No ka hōʻike ʻana i ka hopena o ka huahana, hilinaʻi nui ia i kāna kaʻina hana. I ke kaʻina hana hana huahana, ua lilo ka hoʻoikaika ʻana no ka hopena huahana maikaʻi i mea nui i ka hoʻomohala ʻana.
Kūlana kiʻekiʻetilmicosinpono e loaʻa i nā ʻano ʻehā: makemake nā puaʻa e ʻai, pale ʻōpū, hoʻoheheʻe ʻana o ka ʻōpū a me ka hoʻokuʻu lohi.
01
E hoʻokaʻawale mai ke ʻano
1. He lahilahi loa nā ʻāpana tilmicosin i uhi ʻole ʻia a maʻalahi hoʻi e hoʻoheheʻe ʻia i ka mahana o ka lumi, ʻoiai ʻoi aku ka mānoanoa o nā ʻāpana tilmicosin i uhi ʻia a paʻakikī hoʻi e hoʻoheheʻe ʻia i ka mahana o ka lumi.
2. ʻO ka tilmicosin maikaʻi (e like me Chuankexin i uhi ʻia me nā microcapsules papa pālua) he mau ʻāpana like a poepoe. Ma keʻano laulā, ʻokoʻa ka nui a me ke ʻano like o nā ʻāpana o ka tilmicosin i uhi ʻia.
E hoʻokaʻawale mai ka ʻono i loko o ka waha (maikaʻi ka palatability)
ʻO Tilmicosinʻawaʻawa ka ʻono, a ʻaʻole kūpono ka tilmicosin i uhi ʻole ʻia no ka lawelawe waha. ʻO Tilmicosin me ka ʻono ʻawaʻawa i ka waha ʻaʻole wale ia e hoʻokō i kahi ʻano lāʻau lapaʻau i makemake ʻole ʻia, akā hoʻopilikia nui hoʻi i ka ʻai ʻana o nā puaʻa a hōʻino nui. ʻO ka hoʻonele ʻana i nā lāʻau lapaʻau.
E hoʻokaʻawale mai ka solubility gastric a me ka solubility enteric
1. Ua māhele ʻia ka uhi o ka tilmicosin i ka uhi enteric (kūʻē i ka waikawa akā ʻaʻole kūʻē i ka alkali) a me ka uhi gastric-soluble (ʻaʻole kūʻē i ka waikawa a me ka alkali). E hoʻoheheʻe ʻia a hoʻokuʻu ʻia ka tilmicosin i uhi ʻia me ka gastric-soluble (ʻaʻole kūʻē i ka waikawa a me ka alkali) e ka waikawa gastric i loko o ka ʻōpū, a i ka wā e hoʻokuʻu ʻia ai ka lāʻau lapaʻau, e hoʻoulu ia i ka mucosa gastric e huna i ka wai gastric, a ʻo ka wai gastric nui hiki ke hoʻoulu maʻalahi i ke kahe koko gastric a me nā ʻōpū gastric. Inā hoʻoheheʻe ʻia ka lāʻau lapaʻau i loko o ka ʻōpū a hoʻokuʻu ʻia ma mua, e emi nui ʻia ka bioavailability o ka lāʻau lapaʻau. Ma keʻano laulā, e emi ana ka pono o ka lāʻau lapaʻau i hoʻoheheʻe ʻia i loko o ka ʻōpū ma mua o 10% i hoʻohālikelike ʻia me ka mea i loko o ka ʻōpū. Hoʻonui nui kēia i ke kumukūʻai o ka lāʻau lapaʻau.
2. Uhi ʻōpū (anti-acid akā ʻaʻole anti-alkali) Hiki ke hoʻoheheʻe ʻia a hoʻokuʻu ʻia ka uhi ma o ke kaiapuni waikawa gastric insoluble i loko o ke kaiapuni alkaline o ka ʻōpū, e pale ana i nā hopena ʻaoʻao like ʻole a me nā hopena cardiotoxic i hoʻokumu ʻia e ka hoʻokuʻu mua ʻana i loko o ka ʻōpū. I ka manawa like, hoʻomaikaʻi ʻia ka bioavailability o ka lāʻau lapaʻau i loko o ka ʻōpū. Hoʻokuʻu wikiwiki i loko o ka ʻōpū.
Hoʻohana ka uhi ʻana o ka enteric i nā mea uhi a me nā kaʻina hana like ʻole, a ʻokoʻa hoʻi ka pono o ka hoʻokuʻu ʻana i loko o ka ʻōpū. Hoʻoheheʻe hapa ʻia ka uhi maʻamau a hoʻokuʻu ʻia i loko o ka lua ʻōpū a me ka hopena gastric, kahi ʻokoʻa loa mai ka hopena o ka uhi microcapsule pālua-papa, a wikiwiki ka helu omo ʻana i loko o ke ala ʻōpū.
Ka manawa hoʻouna: Malaki-17-2022