Hoʻonui ka ʻano ʻano ʻokoʻa i ka maʻi o Parkinson mai ka ʻike ʻana i ka pesticide

Hiki i ka ʻike ʻana i nā pyrethroids ke hoʻonui i ka pilikia o ka maʻi o Parkinson ma muli o ka launa pū ʻana me nā genetics ma o ka ʻōnaehana pale.
Loaʻa nā pyrethroids i ka hapa nui o nā ʻoihanapesticides hale. ʻOiai he neurotoxic lākou i nā inike, ua manaʻo ʻia lākou he palekana no ka launa kanaka e nā luna federal.
ʻIke ʻia nā ʻano hoʻololi genetic a me ka ʻike pesticide i ka hopena o ka maʻi o Parkinson. ʻIke ʻia kahi noiʻi hou i kahi loulou ma waena o kēia mau mea pilikia ʻelua, e hōʻike ana i ke kuleana o ka pane ʻana o ka immune i ka holomua o ka maʻi.
Pili nā ʻike i kahi papa opesticideskapa ʻia ʻo pyrethroids, ka mea i loaʻa i ka hapa nui o nā pesticides hale kūʻai a hoʻohana nui ʻia i ka mahiʻai ʻoiai ua hoʻopau ʻia nā pesticides ʻē aʻe. ʻOiai he neurotoxic nā pyrethroids i nā inike, manaʻo mau nā luna federal i palekana no ka ʻike kanaka.
ʻO ke aʻo ʻana ʻo ia ka mea mua e hoʻopili ai i ka ʻike pyrethroid i ka maʻi genetic no ka maʻi o Parkinson a me ka hoʻopaʻa ʻana i nā noiʻi hahai ʻana, wahi a ka mea kākau kiʻekiʻe ʻo Malu Tansi, Ph.D., ke kaukaʻi kumu o ka physiology ma Emory University School of Medicine.
ʻO ka ʻano genetic i ʻike ʻia e ka hui ma ka ʻāina non-coding o ka MHC II (major histocompatibility complex class II) genes, kahi hui o nā genes e hoʻoponopono i ka ʻōnaehana pale.
"ʻAʻole mākou i manaʻo e loaʻa kahi loulou kikoʻī i nā pyrethroids," wahi a Tansey. "Ua ʻike ʻia ʻo ka ʻike nui ʻana i nā pyrethroids hiki ke hoʻopilikia i ka pale ʻana, a ʻo nā molekala a lākou e hana ai hiki ke loaʻa i nā cell immune; Pono mākou e hoʻomaopopo hou e pili ana i ka hopena o ka hopena lōʻihi i ka ʻōnaehana pale a no laila e hoʻonui ai i kāna hana. ʻO ka pilikia o ka maʻi o Kinson.
"Ua loaʻa nā hōʻike ikaika e hiki ke kōkua i ka hoʻomohala ʻana o ka lolo a i ʻole kahi ʻōnaehana pale i ka piʻi ʻana o ka maʻi Parkinson. "Manaʻo mākou i ka mea e hiki mai ana ma ʻaneʻi ʻo ka hoʻolaha ʻana o ke kaiapuni e hoʻololi i ka pane ʻana i ka pale ʻana i kekahi poʻe, e hoʻolaha ana i ka mumū mau i ka lolo."
No ke aʻo ʻana, ua hui pū nā mea noiʻi Emory i alakaʻi ʻia e Tansey lāua ʻo Jeremy Boss, Ph.D., ka luna o ka Department of Microbiology and Immunology, me Stuart Factor, Ph.D., ka luna o Emory's Comprehensive Parkinson's Disease Center, a me Beate Ritz. , MD, Kulanui o Kaleponi, Kapalakiko. Ma ka launa pū ʻana me nā mea noiʻi olakino olakino ma UCLA, Ph.D. ʻO George T. Kannarkat, MD ka mea kākau mua o ka ʻatikala.
Ua hoʻohana nā mea noiʻi ʻo UCLA i kahi waihona ʻāina ʻāina Kaleponi e uhi ana i 30 mau makahiki o ka hoʻohana ʻana i ka pesticide i ka mahiʻai. Ua hoʻoholo lākou i ka ʻike ma muli o ka mamao (ka hana a kekahi a me nā helu home) akā ʻaʻole i ana i nā pae pesticide i ke kino. Manaʻo ʻia e hoʻohaʻahaʻa koke ʻia nā pyrethroids, ʻoi aku ka maikaʻi ke ʻike ʻia i ka lā, me ka hapalua o ke ola o ka lepo o nā lā a i nā pule.
Ma waena o 962 mau kumuhana mai Kaleponi ʻo Central Valley, kahi ʻano MHC II maʻamau i hui pū ʻia me ka ʻike ma luna o ka awelika i nā pesticides pyrethroid i hoʻonui i ka pilikia o ka maʻi o Parkinson. ʻO ke ʻano pōʻino loa o ka moʻo (nā kanaka e lawe ana i ʻelua mau allele pilikia) i loaʻa i 21% o nā maʻi me ka maʻi Parkinson a me 16% o nā mana.
I loko o kēia pūʻulu, ʻaʻole i hoʻonui nui ka ʻike ʻana i ka gene a i ʻole pyrethroid wale nō i ka maʻi o Parkinson, akā ʻo ka hui pū ʻana. Ke hoʻohālikelike ʻia me ka awelika, ʻo ka poʻe i loaʻa i ka pyrethroids a lawe i ke ʻano kiʻekiʻe loa o ka MHC II gene he 2.48 mau manawa ʻoi aku ka nui o ka loaʻa ʻana o ka maʻi Parkinson ma mua o ka poʻe me ka liʻiliʻi o ka ʻike a lawe i ke ʻano haʻahaʻa haʻahaʻa loa o ka gene. pilikia. ʻAʻole e hoʻonui like ka ʻike ʻana i nā ʻano pesticides ʻē aʻe, e like me organophosphates a i ʻole paraquat.
ʻO nā haʻawina genetic ʻoi aku ka nui, ʻo ia hoʻi ʻo Factor a me kāna mau maʻi, ua hoʻopili mua i nā ʻano ʻano gene MHC II i ka maʻi o Parkinson. ʻO ka mea kupanaha, ʻokoʻa ka hopena o ka maʻi o Parkinson i nā Caucasians/Europeans a me ka poʻe Kina. ʻOkoʻa loa nā genes MHC II ma waena o nā kānaka; no laila, he kuleana koʻikoʻi lākou i ke koho ʻana i nā mea hoʻololi o ke kino.
Ua hōʻike ʻia nā hoʻokolohua ʻē aʻe e pili ana nā ʻano like ʻole e pili ana i ka maʻi o Parkinson i ka hana o ka cell immune. Ua ʻike nā mea noiʻi ma waena o 81 mau maʻi maʻi o Parkinson a me nā hoʻomalu ʻEulopa mai ke Kulanui ʻo Emory, ua hōʻike ʻia nā molekele MHC II mai nā poʻe me nā ʻano gene MHC II kiʻekiʻe mai ka haʻawina Kaleponi.
Hoʻokumu nā molekala MHC i ke kaʻina hana o ka "hōʻike antigen" a ʻo ia ka mea hoʻoikaika e hoʻōla i nā cell T a hoʻokomo i ke koena o ka ʻōnaehana pale. Hoʻonui ʻia ka hōʻike MHC II i loko o nā keʻena mālie o nā maʻi maʻi o Parkinson a me nā hoʻomalu olakino, akā ʻike ʻia ka pane ʻoi aku i ka hoʻokūkū immune i nā maʻi maʻi o Parkinson me nā genotypes ʻoi aku ka pilikia;
Ua hoʻopau nā mea kākau: "Ke hōʻike nei kā mākou ʻikepili e ʻoi aku ka maikaʻi o nā biomarkers cellular, e like me ka MHC II activation, ma mua o nā molekele soluble i loko o ka plasma a me ka wai cerebrospinal no ka ʻike ʻana i ka poʻe e pili ana i ka maʻi a i ʻole ke kiʻi ʻana i nā mea maʻi e komo i nā hoʻokolohua o nā lāʻau immunomodulatory." "Ho'āʻo."
Ua kākoʻo ʻia ke aʻo ʻana e ka National Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), ka National Institute of Environmental Health Sciences (5P01ES016731), ka National Institute of General Medical Sciences (GM47310), ʻo Sartainier Family Foundation. ka Michael J. Foxpa Kingson Foundation for Disease Research.