Hoʻonui ka ʻano like ʻole o ka gene immune i ka pilikia o ka maʻi o Parkinson mai ka hōʻike ʻana i nā pesticide

ʻO ka hōʻike ʻana i nā pyrethroids e hoʻonui i ka pilikia o ka maʻi o Parkinson ma muli o ka pilina me nā genetics ma o ka ʻōnaehana pale.
Loaʻa nā Pyrethroids ma ka hapa nui o nā hale kūʻai.nā mea pepehi lāʻau make o ka haleʻOiai he mea ʻawahia lākou i nā pepeke, ua manaʻo ʻia lākou he palekana no ka hoʻopili ʻana me ke kanaka e nā luna aupuni pekelala.
ʻIke ʻia nā ʻokoʻa genetic a me ka hōʻike ʻana i nā pesticides e hoʻopilikia i ka pilikia o ka maʻi Parkinson. Ua ʻike ʻia kahi noiʻi hou i kahi pilina ma waena o kēia mau mea pilikia ʻelua, e hōʻike ana i ke kuleana o ka pane ʻana o ka pale ʻana i ka holomua o ka maʻi.
Pili nā ʻike i kahi papa onā mea pepehi lāʻau makei kapa ʻia he pyrethroids, i loaʻa i ka hapa nui o nā pesticides hale kalepa a ke hoʻohana nui ʻia nei i ka mahiʻai i ka wā e hoʻopau ʻia ai nā pesticides ʻē aʻe. ʻOiai he neurotoxic nā pyrethroids i nā pepeke, manaʻo nā luna aupuni pekelala he palekana lākou no ka hoʻopili ʻana i ke kanaka.
ʻO ke aʻo ʻana ka mea mua e hoʻopili i ka hōʻike ʻana o ka pyrethroid i ka pilikia genetic no ka maʻi Parkinson a pono e hana hou ʻia nā haʻawina hahai, wahi a ka mea kākau koʻikoʻi ʻo Malu Tansi, Ph.D., ke polopeka kōkua o ka physiology ma ke Kula Lapaʻau o ke Kulanui ʻo Emory.
ʻO ke ʻano hoʻoilina i ʻike ʻia e ka hui aia ma ka ʻāpana non-coding o nā genes MHC II (major histocompatibility complex class II), kahi hui o nā genes e hoʻoponopono i ka ʻōnaehana pale.
"ʻAʻole mākou i manaʻo e loaʻa kahi loulou kikoʻī i nā pyrethroids," wahi a Tansey. "Ua ʻike ʻia hiki i ka hōʻike koke ʻana i nā pyrethroids ke hoʻoulu i ka hana ʻole o ka pale ʻana, a hiki ke loaʻa nā molekala a lākou e hana ai i loko o nā pūnaewele pale; Pono mākou e hoʻomaopopo hou aʻe e pili ana i ka hopena o ka hōʻike lōʻihi i ka ʻōnaehana pale a no laila e hoʻonui ai i kāna hana. " Ka pilikia o ka maʻi ʻo Kinson.
"Aia nā hōʻike ikaika e hiki i ka mumū o ka lolo a i ʻole kahi ʻōnaehana pale ikaika ke kōkua i ka holomua o ka maʻi Parkinson. "Manaʻo mākou ʻo ka mea e hana nei ma ʻaneʻi, ʻo ia ka hoʻololi ʻana o nā ʻike kaiapuni i ka pane pale i kekahi poʻe, e paipai ana i ka mumū mau loa i ka lolo."
No ke aʻo ʻana, ua hui pū nā kānaka noiʻi o Emory i alakaʻi ʻia e Tansey lāua ʻo Jeremy Boss, Ph.D., ke poʻo o ka 'Oihana Microbiology a me Immunology, me Stuart Factor, Ph.D., ka luna hoʻokele o ke kikowaena maʻi Parkinson's Comprehensive a Emory, a me Beate Ritz., MD, Ke Kulanui o Kaleponi, Kapalakiko. Ma ka laulima ʻana me nā kānaka noiʻi olakino lehulehu ma UCLA, Ph.D. ʻO George T. Kannarkat, MD ka mea kākau mua o ka ʻatikala.
Ua hoʻohana nā kānaka noiʻi UCLA i kahi waihona ʻikepili honua Kaleponi e uhi ana i 30 mau makahiki o ka hoʻohana ʻana i nā pesticide i ka mahiʻai. Ua hoʻoholo lākou i ka hōʻike ʻana ma muli o ka mamao (ka hana a kekahi a me nā wahi noho o ka home) akā ʻaʻole i ana i nā pae pesticide i loko o ke kino. Manaʻo ʻia e pala koke nā Pyrethroids, ʻoiai ke hōʻike ʻia i ka lā, me ka hapalua ola i ka lepo o nā lā a i nā pule.
Ma waena o 962 mau kumuhana mai Central Valley o Kaleponi, ʻo kahi ʻano MHC II maʻamau i hui pū ʻia me ka ʻike ʻana ma luna o ka awelika i nā pesticides pyrethroid i hoʻonui i ka pilikia o ka maʻi Parkinson. ʻO ke ʻano weliweli loa o ka gene (nā kānaka e lawe ana i ʻelua alleles pilikia) i loaʻa i 21% o nā maʻi me ka maʻi Parkinson a me 16% o nā kaohi.
I loko o kēia hui, ʻo ka hoʻopili ʻana i ka gene a i ʻole pyrethroid wale nō ʻaʻole i hoʻonui nui i ka pilikia o ka maʻi Parkinson, akā ua hana ka hui pū ʻana. Ke hoʻohālikelike ʻia me ka awelika, ʻo ka poʻe i hoʻopili ʻia i nā pyrethroids a lawe i ke ʻano pilikia kiʻekiʻe loa o ka gene MHC II he 2.48 mau manawa ʻoi aku ka nui o ka pilikia o ka hoʻomohala ʻana i ka maʻi Parkinson ma mua o ka poʻe me ka liʻiliʻi o ka hoʻopili ʻana a lawe i ke ʻano pilikia haʻahaʻa loa o ka gene. pilikia. ʻO ka hoʻopili ʻana i nā ʻano pesticides ʻē aʻe, e like me nā organophosphates a i ʻole paraquat, ʻaʻole ia e hoʻonui i ka pilikia ma ke ʻano like.
Ua hoʻopili mua nā haʻawina genetic nui aʻe, me Factor a me kāna mau maʻi, i nā ʻano like ʻole o ka gene MHC II i ka maʻi Parkinson. ʻO ka mea kupanaha, ʻo ka ʻano like ʻole o ka genetic e hoʻopilikia i ka pilikia o ka maʻi Parkinson i nā Caucasians/ʻEulopa a me nā poʻe Kina. ʻOkoʻa loa nā genes MHC II ma waena o nā kānaka; no laila, he kuleana koʻikoʻi kā lākou i ke koho ʻana i nā hoʻoili ʻana o nā kino.
Ua hōʻike ʻia nā hoʻokolohua ʻē aʻe e pili ana nā ʻano like ʻole o ka genetic e pili ana i ka maʻi Parkinson i ka hana o nā cell immune. Ua ʻike nā kānaka noiʻi ma waena o 81 mau maʻi maʻi Parkinson a me nā kaohi ʻEulopa mai ke Kulanui ʻo Emory, ua hōʻike nā cell immune mai ka poʻe me nā ʻano gene MHC II kiʻekiʻe kiʻekiʻe mai ke aʻo ʻana ma Kaleponi i nā molekala MHC hou aku.
ʻO nā molekala MHC ke kumu o ke kaʻina hana o ka "hōʻike antigen" a ʻo ia ka ikaika hoʻokele e hoʻoulu ai i nā cell T a hoʻopili i ke koena o ka ʻōnaehana pale. Hoʻonui ʻia ka hōʻike ʻana o MHC II i loko o nā cell mālie o nā maʻi maʻi Parkinson a me nā kaohi olakino, akā ʻike ʻia ka pane nui ʻana i ka pilikia pale i nā maʻi maʻi Parkinson me nā genotypes kiʻekiʻe;
Ua hoʻoholo nā mea kākau: "Hōʻike kā mākou ʻikepili e ʻoi aku ka pono o nā biomarkers cellular, e like me ka hoʻoulu ʻana o MHC II, ma mua o nā molekala hiki ke hoʻoheheʻe ʻia i loko o ka plasma a me ka wai cerebrospinal no ka ʻike ʻana i nā poʻe i pilikia i ka maʻi a i ʻole no ka hoʻolimalima ʻana i nā maʻi e komo i nā hoʻokolohua o nā lāʻau immunomodulatory." "Hoʻāʻo."
Ua kākoʻo ʻia ke aʻo ʻana e ka National Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), ka National Institute of Environmental Health Sciences (5P01ES016731), ka National Institute of General Medical Sciences (GM47310), ka Sartain Lanier Family Foundation, a me ka Michael J. Foxpa Kingson Foundation for Disease Research.