Pepehi 'o β-Triketone Nitisinone i nā makika kū'ē i ka lāʻau ma ka ʻili | Parasites a Vectors

   ʻO ka lāʻau lapaʻauʻO ke kū'ē i waena o nā arthropods e hoʻoili ana i nā maʻi o ka mahiʻai, holoholona a me ke olakino lehulehu he mea weliweli nui ia i nā papahana hoʻokele vector honua. Ua hōʻike ʻia nā haʻawina mua e loaʻa ana i nā vectors arthropod hoʻokahe koko i ka nui o ka make i ka wā e hoʻokomo ai i ke koko i loko o nā mea paʻa o 4-hydroxyphenylpyruvate dioxygenase (HPPD), ka lua o ka enzyme i loko o ka tyrosine metabolism. Ua nānā kēia haʻawina i ka maikaʻi o ka β-triketone HPPD inhibitors e kūʻē i nā maʻi maʻi a me ka pyrethroid-resistant o ʻekolu mau maʻi maʻi nui, me nā makika e hoʻouna ana i nā maʻi mōʻaukala e like me ka maʻi maʻi maʻi maʻi, nā maʻi hou e like me ka dengue a me Zika, a me nā maʻi e puka mai ana e like me nā maʻi virus Oropuche a me Usutu.

ʻO nā ʻokoʻa ma waena o nā kumuhana topical, tarsal a me vial, nā ʻano noi, ka lawe ʻana i nā insecticide a me ka lōʻihi o ka hana.
Eia nō naʻe, ʻoiai ka ʻokoʻa o ka make ma waena o New Orleans a me Muheza ma ke ʻano kiʻekiʻe loa, ʻoi aku ka maikaʻi o nā ʻike ʻē aʻe a pau ma New Orleans (susceptible) ma mua o Muheza (kū'ē) ma mua o 24 mau hola.
Hōʻike kā mākou mau hopena i ka pepehi ʻana o ka nitisinone i nā makika koko koko ma o ka hoʻopili transtarsal, akā ʻaʻole mesotrione, sulfotrione, a me tepoxiton. ʻAʻole hoʻokae kēia ʻano pepehi kanaka ma waena o nā maʻi makika maʻalahi a kūpaʻa paha i nā ʻano lāʻau insecticides ʻē aʻe, me nā pyrethroids, organochlorines, a me nā carbamates paha. Eia kekahi, ʻaʻole i kaupalena ʻia ka maikaʻi o ka nitisinone i ka pepehi ʻana i nā makika ma o ka epidermal absorption i nā ʻano Anopheles, e like me ka mea i hōʻike ʻia e kona pono e kūʻē iā Strongyloides quinquefasciatus a me Aedes aegypti. Kākoʻo kā mākou ʻikepili i ka pono no ka noiʻi hou ʻana e hoʻonui i ka absorption nitisinone, ma o ka hoʻonui ʻana paha i ke kemika o ka epidermal absorption a i ʻole ka hoʻohui ʻana o nā adjuvants. Ma o kāna ʻano hana hou, hoʻohana ʻo nitisinone i ke ʻano o ka namu wahine. He moho hoʻohiki kēia no nā ʻūhā koena i loko o ka hale a me nā ʻupena insecticidal lōʻihi, ʻoi aku ka maikaʻi ma nā wahi kahi i kūpono ʻole ai nā hana hoʻomalu namu ma muli o ka puka wikiwiki ʻana o ka pale pyrethroid.