Hoʻopau ʻo β-Triketone Nitisinone i nā makika kūʻē i ka pepeke ma o ka omo ʻana o ka ʻili | Nā Parasites a me nā Vectors

   Mea pepehi pepekeʻO ke kū'ē ʻana i waena o nā arthropods e hoʻouna ana i nā maʻi o ka mahiʻai, nā holoholona a me ke olakino lehulehu he hoʻoweliweli koʻikoʻi ia i nā papahana kaohi vector honua. Ua hōʻike ʻia nā haʻawina mua e ʻike ana nā vectors arthropod omo koko i nā helu make kiʻekiʻe i ka wā e ʻai ana i nā mea hoʻopaʻa koko e loaʻa ana i ka 4-hydroxyphenylpyruvate dioxygenase (HPPD), ka lua o ka enzyme i ka metabolism tyrosine. Ua nānā kēia haʻawina i ka pono o nā mea hoʻopaʻa β-triketone HPPD e kūʻē i nā ʻano maʻi kūpono a me nā pyrethroid-resistant o ʻekolu mau vectors maʻi nui, me nā makika e hoʻouna ana i nā maʻi mōʻaukala e like me ka malaria, nā maʻi hou e like me ka dengue a me Zika, a me nā virus e kū mai ana e like me nā virus Oropuche a me Usutu.

Nā ʻokoʻa ma waena o nā ʻano noi topical, tarsal a me ka vial, nā ʻano noi, ka lawe ʻana i nā pepeke pepeke a me ka lōʻihi o ka hana.
Eia nō naʻe, ʻoiai ka ʻokoʻa o ka make ma waena o New Orleans lāua ʻo Muheza ma ka nui kiʻekiʻe loa, ʻoi aku ka maikaʻi o nā ʻano ʻē aʻe ma New Orleans (hiki ke maʻalahi) ma mua o Muheza (kūpaʻa) ma mua o 24 mau hola.
Hōʻike kā mākou mau hopena e pepehi ana ʻo nitisinone i nā makika omo koko ma o ka hoʻopili transtarsal, ʻoiai ʻaʻole ʻo mesotrione, sulfotrione, a me tepoxiton. ʻAʻole hoʻokaʻawale kēia ʻano pepehi kanaka ma waena o nā ʻano makika i maʻalahi a kūʻē paha i nā papa ʻē aʻe o nā insecticides, me nā pyrethroids, organochlorines, a me nā carbamates paha. Eia kekahi, ʻaʻole i kaupalena ʻia ka pono o ka nitisinone i ka pepehi ʻana i nā makika ma o ka absorption epidermal i nā ʻano Anopheles, e like me ka mea i hōʻike ʻia e kona pono kūʻē iā Strongyloides quinquefasciatus lāua ʻo Aedes aegypti. Kākoʻo kā mākou ʻikepili i ka pono no ka noiʻi hou aku e hoʻomaikaʻi i ka absorption nitisinone, malia paha ma o ka hoʻonui ʻana i ka kemika o ka absorption epidermal a i ʻole ka hoʻohui ʻana i nā adjuvants. Ma o kāna ʻano hana hou, hoʻohana ʻo nitisinone i ke ʻano omo koko o nā makika wahine. ʻO kēia ka mea e lilo ai ia i moho hoʻohiki no nā pīpī koena hou o loko a me nā ʻupena insecticidal lōʻihi, ʻoi aku hoʻi ma nā wahi kahi i kūpono ʻole ai nā ʻano hana kaohi makika kuʻuna ma muli o ka puka koke ʻana o ke kūʻē pyrethroid.