ʻO ka lāʻau lapaʻau holoholona maikaʻi ʻo Colistin Sulfate CAS 1264-72-8
Hōʻike huahana
Loaʻa iā ia ka hopena antibacterial ikaika i ka gram-negative bacteria, a ʻo nā maʻi maʻi koʻikoʻi e komo pū me Pseudomonas aeruginosa, Escherichia coli, Enterobacteria, Klebsiella, Salmonella, Shigella, Pasteurella a me Vibrio. ʻO Proteus, Brucella, Serratia a me nā bacteria Gram-positive āpau i kūʻē i kēia huahana.ʻO Colistin Sulfateno ka lohi disinfectant, ka hana nui i loko o ka bacteria cell membranes, i ka wā e launa pū me sensitive bacteria, kona kemika hoʻolālā o ka noa amino (Yang) a me ka phosphate ester o ka phosphoric acid aʻa ma ka bacterial cell membrane (me electronegative), e hoʻonui i ka permeability o ka membrane, e hoʻoulu ana i ka cell o nā mea nui e like me nā amino acids, nā mele Piao, pyrimidine, K + ona.
Application
Hoʻohana nui ʻia e mālama i nā maʻi ʻōpū i hana ʻia e ka Grame-negative bacilli (Escherichia coli, etc.). He mea maikaʻi hoʻi ia e kūʻē iā Pseudomonas aeruginosa (sepsis, maʻi maʻi urinary, kuni a i ʻole ka maʻi ʻeha traumatic).
Nā hiʻohiʻona
(1) He kūʻē ikaika loa ia i ka maʻi bacteria Gram negative. ʻO ka mea nui, loaʻa iā ia kahi hopena hoʻomohala kūikawā ma Escherichia coli, Salmonella, a me Pseudomonas aeruginosa.
(2) He hopena bactericidal kona. Ma ka pale ʻana i ka hana koho permeability o nā membrane cell, make ka bacteria.
(3) Aneane ʻaʻohe pilikia me ke kūʻē ʻana i ka lāʻau. ʻAʻole i ʻike ʻia ke kūʻē i ka R-factor.
(4) He hana synergistically ia me nā lāʻau anti-Gram positive bacteria. Ke hui pū ʻia me ka zinc bacitracin, flavomycin, sulfonamides, semi synthetic penicillin, gentamicin, etc., ʻoi aku ka maikaʻi o ka hopena.
(5) ʻAʻohe koena. Ke hāʻawi waha ʻia, ʻaneʻane ʻaʻole i komo ʻia e ka ʻōpū, akā i ka wā o ka intramuscular injection, maikaʻi ka hōʻiliʻili koko a me ka absorption, no laila ʻaʻohe pono e hopohopo e pili ana i nā koena o nā huahana holoholona.
(6) Hoʻoikaika i ka ulu ʻana o nā holoholona a me nā moa, a pale a hoʻomalu i ka enteritis infectious i nā holoholona a me nā moa.
