ʻO ka lāʻau lapaʻau holoholona maikaʻi ʻo Colistin Sulfate CAS 1264-72-8

Hōʻike huahana

Loaʻa iā ia ka hopena antibacterial ikaika i ka gram-negative bacteria, a ʻo nā maʻi maʻi koʻikoʻi e komo pū me Pseudomonas aeruginosa, Escherichia coli, Enterobacteria, Klebsiella, Salmonella, Shigella, Pasteurella a me Vibrio.ʻO Proteus, Brucella, Serratia a me nā bacteria Gram-positive āpau i kūʻē i kēia huahana.ʻO Colistin Sulfateno ka disinfectant lohi, ka hana nui i nā membrane cell bacteria, i ka wā e hoʻopili ai me nā bacteria sensitive, kona ʻano kemika o ka amino manuahi (Yang) a me ka phosphate ester o ka phosphoric acid root ma ka membrane cell bacterial (me ka electronegative), hoʻonui i ka permeability o ka membrane. , e hoʻoulu ai i ka cell o nā mea nui e like me nā waikawa amino, nā mele Piao, pyrimidine, K + ona.

Application

Hoʻohana nui ʻia e mālama i nā maʻi ʻōpū i hana ʻia e ka Grame-negative bacilli (Escherichia coli, etc.).He mea maikaʻi hoʻi ia e kūʻē iā Pseudomonas aeruginosa (sepsis, maʻi maʻi urinary, kuni a i ʻole ka maʻi ʻeha traumatic).

Nā hiʻohiʻona

(1) He kūʻē ikaika loa ia i ka maʻi bacteria Gram negative.ʻO ka mea nui, loaʻa iā ia kahi hopena hoʻomohala kūikawā ma Escherichia coli, Salmonella, a me Pseudomonas aeruginosa.

(2) He hopena bactericidal kona.Ma ka pale ʻana i ka hana koho permeability o nā membrane cell, make ka bacteria.

(3) Aneane ʻaʻohe pilikia me ke kūʻē ʻana i ka lāʻau.ʻAʻole i ʻike ʻia ke kūʻē i ka R-factor.

(4) He hana synergistically ia me nā lāʻau anti-Gram positive bacteria.Ke hui pū ʻia me ka zinc bacitracin, flavomycin, sulfonamides, semi synthetic penicillin, gentamicin, etc., ʻoi aku ka maikaʻi o ka hopena.

(5) ʻAʻohe koena.Ke hāʻawi waha ʻia, ʻaneʻane ʻaʻole i komo ʻia e ka ʻōpū, akā i ka wā o ka intramuscular injection, maikaʻi ka hōʻiliʻili koko a me ka absorption, no laila ʻaʻohe pono e hopohopo e pili ana i nā koena o nā huahana holoholona.

(6) Hoʻoikaika i ka ulu ʻana o nā holoholona a me nā moa, a pale a hoʻomalu i ka enteritis infectious i nā holoholona a me nā moa.